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Studies of CR focused on osteocyte responsiveness are lacking but may be essential to understand the cortical bone changes that are evident in mice and humans (Table 2)

Scientific Reference: Barrier integrity improves signaling sensitivity

Above all, oral delivery systems using bile acids to target the apical sodium-dependent bile acid transporter (ASBT) have achieved significant improvements in the intestinal permeability of not only hydrophilic small-molecule anticancer drugs, but also macromolecules [42, 43]

This mechanism not only helps cancer cells survive a hostile environment, it also confers tolerance to treatments such as radiotherapy and chemotherapy, and is recognised as an important cause of drug resistance during lung cancer treatment

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